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Fityk diameter7/26/2023 ![]() ![]() PVA is a chemically stable water soluble, non-toxic, biocompatible and biodegradable polymer with good film and fiber forming properties. To overcome this problem, CS dissolved in acidic aqueous solution is mixed with nonionic polymer solutions such as poly(vinyl alcohol) (PVA) improving the viscoelastic properties and the electrospinability of the CS solution. However, chitosan is not soluble in organic solvents, and its aqueous solutions are not electrospinnable. Such information reinforces that chitosan can be a potential biomaterial for tissue engineering, including the production of nanofibers for topical drug administration. In studies involving the use of chitosan as biomaterial, in addition to mechanical properties, chondrocyte proliferation and extracellular matrix production, such as glycosaminoglycans and type I and type II collagen, were verified. Due to these characteristics, chitosan can be considered a promising biomaterial, which can be used for the preparation of several drug delivery systems, including nanofibers. ![]() In addition, it does not cause allergic reactions or rejection problems, has bioadhesive properties, increases the residence time of chitosan-based systems at specific absorption sites, controlled release and improved bioavailability, and has antimicrobial activity. This biopolymer has characteristics such as hydrophilicity, biodegradability, biocompatibility and low toxicity. Furthermore, the electrospinning process allows the spinning of a wide variety of polymers, natural or synthetic, such as the combination of these polymers.Ĭhitosan (CS) is composed of repeating units of 2-acetamido-2-deoxy-D-glycopyranose (N-acetylglycosamine) joined by β-(1→4) bonds. In addition, depending on the polymer used, a wide range of properties such as strength, porosity, functionalized surface may be achieved. Due to the inherent properties of the electrospinning process, the arrangement of polymeric fibers can be controlled with the aim of obtaining complex and three-dimensional nanofibers. Achieving these characteristics depends on a wide range of factors such as solution parameters (polymer concentration, conductivity and viscosity), process-related parameters (polymer flow rate, distance tip-to-plate, and applied voltage), as well as humidity and temperature. Fibers produced by electrospinning have controlled dimensions, about a few nanometers, and porosity, which give the produced fibers a high surface area. The mats were crosslinked with glutaraldehyde for 24 h and 48 h and presented good water stability and enhanced mechanical properties.Įlectrospinning, Poly(Vinyl Alcohol), Chitosan, Box-Behnken DesignĮlectrospinning is a promising and versatile technique that is used to fabricate polymeric nanofibers for a wide variety of biomedical applications such as drug delivery systems, scaffolds for tissue engineering, wound dressing. The desirability function allied with Box-Benhken design proved themselves important tools to predict process parameters for the development of nanofibers. The fiber diameter and standard deviation were 196.5 ± 28.3 nm, compared to the predicted values of 185.9 ± 26.8 nm. With desirability function, the optimal conditions to produce the nanofibers were applied voltage of 13.1 kV, 30% chitosan concentration and distance tip-to-plate of 10 cm. An empirical model was developed for each response using response surface methodology (RSM), which revealed that flow rate had no significant influence on the assessed responses. Four factors (applied voltage, flow rate, distance tip-to-plate and amount of chitosan) were varied to produce electrospun mats with a low fiber diameter. Received: MaAccepted: ApPublished: April 20, 2020Įlectrospun poly(vinyl alcohol)/chitosan nanofibers had their solution and process parameters optimized using a Box-Behnken design and desirability function. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). ![]() 1Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco J, Rio de Janeiro, BrazilĢDepartmento de Ciências Naturais, Universidade Federal do Estado do Rio de Janeiro, Avenida Pasteur, Rio de Janeiro, BrazilĬopyright © 2020 by author(s) and Scientific Research Publishing Inc. ![]()
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